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Benzene phosphorus thiamine

Name：Benzene phosphorus thiamine

CAS: 22457-89-2

MF:C₁₉H₂₃N₄O₆PS

MW: 466.45

Structural formula：

Density: 1. 444 g/mL at 25 °C、

Boiling point: 745.1 °C (20 mmHg)

Flash point: 404.4°C

Assay: 98.0—102.0%

Appearance: white or almost white crystalline powder

Application: Benzene phosphorus thiamine is vitamin B1 fat soluble derivatives, improve the bioavailability of water-soluble vitamin B1 low shortcomings, improve the blood and tissue concentrations of thiamine, so as to improve the curative effect. Benzene phosphorus thiamine already in the United States, Japan, Europe and other parts of the world wide market, its dosage forms listed dosage forms such as tablets, granules, indications are: A. is used for the prevention and treatment of vitamin B1 deficiency; B. for vitamin B1 demand increase, with inadequate intake from foods supplies (fatigue, hyperthyroidism, pregnancy, lactation, during strenuous manual labor, etc.); C. is used in the treatment of non alcoholic wernicke encephalopathy; D. to treat beriberi; E. used in the following diseases, speculation and vitamin B1 deficiency and metabolic disorders associated with treatment, such as: neuralgia; Muscle pain, joint pain; Peripheral neuritis, peripheral nerve palsy; Myocardial metabolic disorders; Constipation and other gastrointestinal motor function obstacle.

Test Item	Analysis Specification
Description	White to almost white crystal
Identification	A: IR spectra shows the similarity between sample and standard B: The retention time of the major peak corresponds with it of the reference standard
Solution color and clearness	Colorless to pale-yellow clear solution
Chlorides	Not more than 0.053%
Sulphate	Not more than 0.011%
Loss on drying	Not more than 1.5%
Heavy metals	Not more than 0.002%
Related Substances	TMP :Not more than 0.15% Benzoic acid :not more than0.1% Amide: not more than 0.40% Single unknown impurity: not more than0.1% Thiamine: not more than0.1% Total impurities: Not more than 1.5%
Residual solvents	Dichloromethane: not more than 600ppm Isopropanol: not more than300ppm
Microbial limits	Total bacteria: not more than100cfu/g Yeast and mould: not more than50cfu/g Escherichia coli: no detectable
Assay(Dry Basis)	98.0%~102.0%

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